THE EFFECTS OF AEROBIC, RESISTANCE, AND COMBINED EXERCISE ON C1Q/TNF-RELATED PROTEIN-5 (CTRP-5) LEVELS AND GLYCEMIC PARAMETERS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Background: It has been shown that C1q TNF-related protein 5 (CTRP5) is a novel adipokine and important molecule related to metabolism regulation. This study aims to assess the effectiveness of different training protocols on improving serum levels of CTRP5, fasting blood glucose, insulin, Insulin resistance in patients with T2DM. Methods: Sixty men with T2DM (mean age [X̅±SD]=51.45±4.26 years) were randomly assigned to combined  exercise group (CEx: n = 15), aerobic  exercise group (AEx: n = 15), resistance  exercise group (REx: n = 15), or the control group (CON: n= 15). Exercise programs consisted of aerobic exercises at either AEx (50% - 75% of HRR) or REx (70% - 85% of 1-RM), of equal volume, 3 times per week, 45 to 60 minutes per session for 12 weeks. Serum levels of CTRP5, fasting blood glucose (FBG), insulin, Insulin resistance (IR) and body mass index (BMI) were measured at baseline and at the end of the study. The data were analyzed using repeated-measures analysis of variance. Results: After 12 weeks intervention, FBG, insulin, HOMA-IR and BMI levels decreased significantly, whereas the serum CTRP5 levels increased in the CEx, AEx and Rex groups compared to control (P < .05). Conclusion: It appears that the increased levels of CTRP5 following exercise interventions contribute to the decreased risk of T2DM.